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1: FEBS Lett. 1997 Jul 28;412(2):285-9.Click here to read Links

Differential action of AGCF2 upon cell type-dependent expression of human angiotensinogen gene.

Yanai K, Matsuyama S, Murakami K, Fukamizu A.

Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

To investigate the regulatory mechanisms of human angiotensinogen (ANG) gene expression in the brain, we analyzed the 1.3-kb promoter by transfection studies and gel shift assays. The region from -106 to +44 was sufficient for promoter activity in glioblastoma cells, and multiple nuclear factors including AGCF2 (human ANG core promoter binding factor 2) bound within this 150-bp region. The mutations within AGCF2-binding elements decreased the transcriptional activity in glioblastoma cells but rather increased it in hepatoma cells. These results indicate that AGCF2 has a differential function between these cells and contributes to the glia-dependent angiotensinogen promoter activity.

PMID: 9256236 [PubMed - indexed for MEDLINE]

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