Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1997 Jul;22(7):257-61.

Guiding ribose methylation of rRNA.

Author information

  • 1Laboratoire de Biologie Moléculaire Eucaryote du CNRS, Université Paul-Sabatier, Toulouse, France. bachel@ibcg.biotoul.fr

Abstract

Eukaryotic rRNAs contain a complex set of ribose-methylated nucleotides. Why are these nucleotides modified and how are they selected? A large family of small nucleolar RNAs (snoRNAs) with long complementarities to sites of rRNA methylation has been recently found to guide such modifications, opening up a direct approach to the study of their elusive function. Ribose methylation can also be targeted to non-rRNA sequences by tailored snoRNA guides, possibly providing a highly selective tool for altering gene expression at the post-transcriptional level.

PMID:
9255067
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk