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1: J Ethnopharmacol. 1997 Jul;57(2):93-6.Click here to read Links

Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs.

Sharma SS, Kochupillai V, Gupta SK, Seth SD, Gupta YK.

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.

Effect of ginger (Zingiber officinale Roscoe, Zingiberaceae) extracts (acetone, 50% ethanolic and aqueous) were investigated for antiemetic activity against emesis induced by 3 mg/kg cisplatin (the 100% emetic dose i.v.) in-healthy mongrel dogs. The acetone and 50% ethanolic extract at the doses of 25, 50, 100 and 200 mg/kg p.o. exhibited significant protection while aqueous extract at these doses was ineffective against cisplatin emesis. The acetone extract was more effective than ethanolic extract. However, both were less effective when compared to 5-HT3 receptors antagonist-granisetron. Neither of the ginger extract was effective against apomorphine-induced emesis. The findings suggest that ginger could be an effective and cheap antiemetic adjunct to cancer chemotherapy.

PMID: 9254112 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Cisplatin (Platinol®-AQ)

    Your doctor has ordered the drug cisplatin to help treat your illness. The drug is given by injection into a vein.

  • Apomorphine (Apokyn® )

    Apomorphine is used to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in patients with Parkinson's disease (PD; a disorder of the nervous s...

  • Granisetron (Kytril® )

    Granisetron is used to prevent nausea and vomiting caused by cancer chemotherapy and radiation therapy. Granisetron is in a class of medications called 5-HT3 antagonists. It works by blocking serotonin, a natural substan...

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