PubMed

Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN.

van 't Veer C, Kalafatis M, Bertina RM, Simioni P, Mann KG.

J Biol Chem. 1997 Aug 15;272(33):20721-9.PMID: 9252393 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of activated protein C with serpins.

Hermans JM, Stone SR.

Biochem J. 1993 Oct 1;295 ( Pt 1):239-45.PMID: 8216224 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanism of inactivation of human factor V and human factor Va by activated protein C.

Kalafatis M, Rand MD, Mann KG.

J Biol Chem. 1994 Dec 16;269(50):31869-80.PMID: 7989361 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of dalteparin (Fragmin) on thrombin generation in pregnant women with venous thromboembolism: significance of the factor V Leiden mutation.

Schambeck CM, Eberl E, Geisen U, Grossmann R, Keller F.

Thromb Haemost. 2001 May;85(5):782-6.PMID: 11372668 [PubMed - indexed for MEDLINE]Related articles

Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V.

Samis JA, Garrett M, Manuel RP, Nesheim ME, Giles AR.

Blood. 1997 Aug 1;90(3):1065-74.PMID: 9242537 [PubMed - indexed for MEDLINE]Related articlesFree article

Does activated protein C-resistant factor V contribute to thrombin generation in hemophilic plasma?

Bos MH, Meijerman DW, van der Zwaan C, Mertens K.

J Thromb Haemost. 2005 Mar;3(3):522-30.PMID: 15748243 [PubMed - indexed for MEDLINE]Related articles

The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase.

Bukys MA, Orban T, Kim PY, Nesheim ME, Kalafatis M.

Thromb Haemost. 2008 Mar;99(3):511-22.PMID: 18327399 [PubMed - indexed for MEDLINE]Related articles

Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.

Gale AJ, Cramer TJ, Rozenshteyn D, Cruz JR.

J Biol Chem. 2008 Jun 13;283(24):16355-62. Epub 2008 Apr 18.PMID: 18424440 [PubMed - indexed for MEDLINE]Related articlesFree article

Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.

Pittman DD, Tomkinson KN, Michnick D, Selighsohn U, Kaufman RJ.

Biochemistry. 1994 Jun 7;33(22):6952-9.PMID: 8204629 [PubMed - indexed for MEDLINE]Related articles

Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.

Safa O, Morrissey JH, Esmon CT, Esmon NL.

Biochemistry. 1999 Feb 9;38(6):1829-37.PMID: 10026263 [PubMed - indexed for MEDLINE]Related articles

A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.

Bukys MA, Kim PY, Nesheim ME, Kalafatis M.

J Biol Chem. 2006 Dec 22;281(51):39194-204. Epub 2006 Oct 4.PMID: 17020886 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin generation in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. A pilot study.

Couturaud F, Duchemin J, Leroyer C, Delahousse B, Abgrall JF, Mottier D; Groupe d'Etude de la Thrombose de Bretagne Occidentale (G.E.T.B.O).

Thromb Haemost. 2008 Jan;99(1):223-8.PMID: 18217158 [PubMed - indexed for MEDLINE]Related articles

Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.

van der Neut Kolfschoten M, Dirven RJ, Vos HL, Tans G, Rosing J, Bertina RM.

J Biol Chem. 2004 Feb 20;279(8):6567-75. Epub 2003 Dec 2.PMID: 14660667 [PubMed - indexed for MEDLINE]Related articlesFree article

The factor V activation paradox.

Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG.

J Biol Chem. 2004 May 7;279(19):19580-91. Epub 2004 Feb 24.PMID: 14982929 [PubMed - indexed for MEDLINE]Related articlesFree article

Human platelets contain forms of factor V in disulfide-linkage with multimerin.

Hayward CP, Fuller N, Zheng S, Adam F, Jeimy SB, Horsewood I, Quinn-Allen MA, Kane WH.

Thromb Haemost. 2004 Dec;92(6):1349-57.PMID: 15583744 [PubMed - indexed for MEDLINE]Related articles

Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.

Nicolaes GA, Villoutreix BO, Dahlbäck B.

Biochemistry. 1999 Oct 12;38(41):13584-91.PMID: 10521265 [PubMed - indexed for MEDLINE]Related articles

Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex.

Deguchi H, Takeya H, Gabazza EC, Nishioka J, Suzuki K.

Biochem J. 1997 Feb 1;321 ( Pt 3):729-35.PMID: 9032460 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin-catalyzed activation of human coagulation factor V.

Suzuki K, Dahlbäck B, Stenflo J.

J Biol Chem. 1982 Jun 10;257(11):6556-64.PMID: 7076681 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural requirements for expression of factor Va activity.

Kalafatis M, Beck DO, Mann KG.

J Biol Chem. 2003 Aug 29;278(35):33550-61. Epub 2003 Jun 4.PMID: 12788947 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test.

Curvers J, Thomassen MC, Rimmer J, Hamulyak K, van der Meer J, Tans G, Preston FE, Rosing J.

Thromb Haemost. 2002 Jul;88(1):5-11.PMID: 12152677 [PubMed - indexed for MEDLINE]Related articles