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Science. 1997 Aug 15;277(5328):942-6.

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

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  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.

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PMID:
9252323
[PubMed - indexed for MEDLINE]
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