Med Hypotheses. 1997 Jun;48(6):473-6.

Does excessive adenosine 5'-triphosphate formation in cells lead to malignancy? A hypothesis on cancer.

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Department of Biochemistry, University College of Science, University of Calcutta, India.

Abstract

In biological systems, adenosine triphosphate (ATP) is the principal contributor of free energy necessary for anabolic reactions and is also a precursor of nucleic acids. Moreover, active transport of metabolites into cells is also driven by hydrolysis of ATP. So, a cell may grow, multiply and ultimately turn malignant when it has been transformed in such a manner that it produces excess ATP as compared with its usual metabolic demand. Recent studies have indicated that mitochondrial complex I and the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) may be critically altered specifically in malignant cells. So, we further propose that this excessive ATP formation may be due to altered mitochondrial complex I and GA3PD of malignant cells.

PMID:: 9247887; [PubMed - indexed for MEDLINE]

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