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Science. 1997 Aug 8;277(5327):818-21.

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

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  • 1Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.

Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

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PMID:
9242611
[PubMed - indexed for MEDLINE]
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