Annu Rev Biophys Biomol Struct. 1997;26:373-99.

Single-particle tracking: applications to membrane dynamics.

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Institute of Theoretical Dynamics, University of California, Davis 95616, USA. mjsaxton@ucdavis.edu

Abstract

Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics.

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