Annu Rev Nutr. 1997;17:405-33.

Regulation of the expression of lipogenic enzyme genes by carbohydrate.

Source

Department of Biochemistry and the Institute of Human Genetics, University of Minnesota, Minneapolis 55455, USA.

Abstract

Diets high in simple carbohydrates and low in fats lead in the mammalian liver to induction of a set of enzymes involved in lipogenesis. This induction occurs, in part, through transcriptional mechanisms that lead to elevated levels of the mRNA for these enzymes. For most of the lipogenic enzymes, an increase in glucose metabolism is required to trigger the transcriptional response. The intracellular mediator of this signaling pathway is unknown, although evidence suggests either glucose-6-phosphate or xylulose-5-phosphate. Studies to map the regulatory sequences of lipogenic enzyme genes involved in the transcriptional response have been performed for the L-type pyruvate kinase, S14, and acetyl-coenzyme A carboxylase genes. These studies have identified the DNA sequences necessary to link the signal generated by carbohydrate metabolism to specific nuclear transcription factors.

PMID:: 9240934; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

[Regulation of expression of genes coding for lipogenesis enzymes during development in the rat]. [Bull Mem Acad R Med Belg. 1995]
[Regulation of expression of genes coding for lipogenesis enzymes during development in the rat].
Girard J, Prip-Buus C, Perdereau D, Foufelle F, Maury J, Ferre P. Bull Mem Acad R Med Belg. 1995; 150(1-2):87-93; discussion 93-4.
Review Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. [Annu Rev Nutr. 1997]
Review Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes.
Girard J, Ferré P, Foufelle F. Annu Rev Nutr. 1997; 17:325-52.
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. [J Biol Chem. 1999]
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, et al. J Biol Chem. 1999 Dec 10; 274(50):35832-9.
Nutritional regulation of lipogenic enzyme gene expression in rat epididymal adipose tissue. [J Biochem. 1996]
Nutritional regulation of lipogenic enzyme gene expression in rat epididymal adipose tissue.
Iritani N, Fukuda H, Tada K. J Biochem. 1996 Aug; 120(2):242-8.
Review Regulation of lipogenic enzyme gene expression by nutrients and hormones. [FASEB J. 1994]
Review Regulation of lipogenic enzyme gene expression by nutrients and hormones.
Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferré P. FASEB J. 1994 Jan; 8(1):36-42.

See reviews... See all...

Cited by 27 PubMed Central articles

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. [Proc Natl Acad Sci U S A. 2011]
Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.
Gachon F, Leuenberger N, Claudel T, Gos P, Jouffe C, Fleury Olela F, de Mollerat du Jeu X, Wahli W, Schibler U. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4794-9. Epub 2011 Mar 7.
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). [Biochem Biophys Res Commun. 2010]
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP).
Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Biochem Biophys Res Commun. 2010 May 7; 395(3):395-400. Epub 2010 Apr 9.
Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. [Circ Res. 2010]
Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans.
Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, et al. Circ Res. 2010 Apr 16; 106(7):1303-11. Epub 2010 Feb 25.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of the expression of lipogenic enzyme genes by carbohydrate.
Regulation of the expression of lipogenic enzyme genes by carbohydrate.
Annu Rev Nutr. 1997 ;17:405-33.

PubMed
Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform ...
Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3.
Biochem J. 1992 Nov 15 ;288 ( Pt 1):309-14.

PubMed
Succinimide formation at Asn 55 in the complementarity determining region of a r...
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.
J Pharm Sci. 2009 Oct ;98(10):3509-21.

PubMed
Constitutional FLCN mutations in patients with suspected Birt-Hogg-Dubé syndrome...
Constitutional FLCN mutations in patients with suspected Birt-Hogg-Dubé syndrome ascertained for non-cutaneous manifestations.
Clin Genet. 2011 Apr ;79(4):345-54. doi: 10.1111/j.1399-0004.2010.01480.x.

PubMed
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
Nature. 1998 Jan 1 ;391(6662):82-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Regulation of the expression of lipogenic enzyme genes by carbohydrate.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 27 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information