Adv Exp Med Biol. 1997;413:149-53.

Assessment of local brain activation. A simultaneous PET and near-infrared spectroscopy study.

Villringer K, Minoshima S, Hock C, Obrig H, Ziegler S, Dirnagl U, Schwaiger M, Villringer A.

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Department of Radiology, Benjamin-Franklin Hospital, Berlin, Germany.

Abstract

In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously. Changes in [oxy-Hb], [deoxy-Hb] and [total-Hb] as measured by NIRS over the left forehead were compared to measurements of cerebral blood flow by PET during rest and during performance of a calculation task and a Stroop task. When a penetration depth of near-infrared light 0.9 cm into the brain cortex was assumed, a statistically significant correlation between changes in CBF and changes in [total-Hb] was found. These data confirm the validity of NIRS measurements in human adults.

PMID:: 9238495; [PubMed - indexed for MEDLINE]

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