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Semin Immunol. 1997 Aug;9(4):235-40.

Regulation of B-cell commitment to plasma cells or to memory B cells.

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  • 1Laboratory for Immunological Research, Schering-Plough, Dardilly, 69571, France.


During humoral immune responses, B-lymphocyte activation is followed by differentiation along either the plasma cell pathway or the memory B-cell pathway. Recent studies suggest that CD40-CD40 ligand, OX-OX40 ligand, a group of cytokines and intracellular transcriptional factors may all contribute to B-lymphocyte differentiation control.

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