J Ethnopharmacol. 1997 Jun;57(1):11-20.

Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse.

Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F.

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Laboratoire d'Ethnobotanique et de Pharmacologie, Université de Metz, France.

Abstract

Lyophilised hydroalcoholic and aqueous extracts of the aerial parts of Passiflora incarnata L. (Passifloraceae) (Passion-flower), as well as chemical constituents of the plant, indole alkaloids (harman, harmin, harmalin, harmol, and harmalol) maltol and flavonoids (orientin, isoorientin, vitexin and isovitexin) were assessed for behavioral effects in mice. The accordance with the traditional use of P. incarnata, psychotropic properties were confirmed by some behavioral tests in mice. The anxiolytic properties of hydroalcoholic extract were confirmed at 400 mg/kg by the increase of rears and steps climbed in the staircase test (non-familiar environmental test), and the increase in locomotion and time spent in light side in the light/dark box choice test (non-familiar environmental test). The sedative properties of aqueous extract were confirmed at 400 g/kg by decrease of rears and steps climbed in the staircase test and the decrease of rears and locomotion in the free exploratory test. Moreover, the aqueous extract induced sleep in mice after treatment with a sub-hypnotic dose of pentobarbital.

PMID:: 9234160; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. [Phytomedicine. 2010]
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method.
Elsas SM, Rossi DJ, Raber J, White G, Seeley CA, Gregory WL, Mohr C, Pfankuch T, Soumyanath A. Phytomedicine. 2010 Oct; 17(12):940-9. Epub 2010 Apr 10.
Review Risks and benefits of commonly used herbal medicines in Mexico. [Toxicol Appl Pharmacol. 2008]
Review Risks and benefits of commonly used herbal medicines in Mexico.
Rodriguez-Fragoso L, Reyes-Esparza J, Burchiel SW, Herrera-Ruiz D, Torres E. Toxicol Appl Pharmacol. 2008 Feb 15; 227(1):125-35. Epub 2007 Oct 12.
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. [BMC Complement Altern Med. 2007]
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Nassiri-Asl M, Shariati-Rad S, Zamansoltani F. BMC Complement Altern Med. 2007 Aug 8; 7:26. Epub 2007 Aug 8.

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