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    Endocrinology. 1997 Aug;138(8):3555-8.

    Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter.

    Smanik PA, Ryu KY, Theil KS, Mazzaferri EL, Jhiang SM.

    Department of Physiology, The Ohio State University, Columbus 43210, USA.

    The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS). In this report, we show that hNIS expression was detected primarily in thyroid tissue, but also in breast, colon, and ovary tissues. Expression of hNIS is greatly reduced in thyroid tumors compared to normal thyroid tissue. Among tumor tissues, hNIS expression appears to be variable, consistent with the variable response to radioiodide treatment observed for thyroid carcinomas. The coding region of hNIS is interrupted by 14 introns, and the nucleotide sequence of each exon-intron junction is reported. Using this information, an alternatively spliced form of hNIS was identified. Finally, the chromosome location of the hNIS gene was mapped to chromosome 19p.

    PMID: 9231811 [PubMed - indexed for MEDLINE]

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      Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...

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