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Cell Mol Life Sci. 1997 Jun;53(6):516-21.

Three-dimensional structure of annexins.

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  • 1Abteilung für Strukturforschung, Max-Planck-Institut für Biochemie, Martinsried, Germany. liemann@mol.biol.ethz.ch


Annexins constitute a family of structurally related calcium- and phospholipid-binding proteins whose molecular structure has been investigated in detail in the crystalline and membrane-bound form. Their polypeptide chain is folded into four or eight alpha-helical domains of similar structure with a central hydrophilic pore. Bound to phospholipid membranes, the four-domain arrangement of the annexin molecule is conserved. A peripheral binding mode has been well documented by electron microscopy and a variety of other techniques.

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