Cloning and subcellular localization of hamster an...[J Biol Chem. 1997]

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1: J Biol Chem. 1997 Jul 25;272(30):18945-50. Links

Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes.

Paton VG, Shackelford JE, Krisans SK.

Department of Biology, San Diego State University, San Diego, California 92182, USA.

To date, isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase; EC 5.3.3.2) is presumed to have a cytosolic localization. However, we have recently shown that in permeabilized cells lacking cytosolic components, mevalonate can be converted to cholesterol, implying that all of the enzymes required for the conversion of mevalonate to farnesyl diphosphate are found in the peroxisome. To provide unequivocal evidence for the subcellular localization of IPP isomerase, in this study, we have cloned the rat and hamster homologues of IPP isomerase and identified the signal that targets this enzyme to peroxisomes. In addition, we also demonstrate that IPP isomerase is regulated at the mRNA level.

PMID: 9228075 [PubMed - indexed for MEDLINE]

Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes.
J Biol Chem. 1996 Jan 19; 271(3):1784-8.

[J Biol Chem. 1996]
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[EMBO J. 2001]
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Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylal...Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes.

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Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes.

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Cited by 4 PubMed Central articles

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