Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress

Planta Med. 1997 Jun;63(3):265-6. doi: 10.1055/s-2006-957669.

Abstract

Curcuminoids from Curcuma longa L. (Zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. Since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect.

Publication types

  • Letter

MeSH terms

  • Antioxidants*
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Curcumin / analogs & derivatives*
  • Curcumin / pharmacology*
  • Epidermal Cells
  • Humans
  • Infant, Newborn
  • Keratinocytes / cytology
  • Keratinocytes / drug effects*
  • Keratinocytes / physiology
  • Male
  • Oxidative Stress*
  • Skin / cytology*
  • Spices*
  • Superoxides / metabolism

Substances

  • Antioxidants
  • Superoxides
  • Curcumin