Abstract
Curcuminoids from Curcuma longa L. (Zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. Since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect.
MeSH terms
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Antioxidants*
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Cell Division / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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Curcumin / analogs & derivatives*
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Curcumin / pharmacology*
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Epidermal Cells
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Humans
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Infant, Newborn
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Keratinocytes / cytology
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Keratinocytes / drug effects*
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Keratinocytes / physiology
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Male
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Oxidative Stress*
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Skin / cytology*
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Spices*
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Superoxides / metabolism
Substances
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Antioxidants
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Superoxides
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Curcumin