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Neuropharmacology. 1997 Apr-May;36(4-5):419-28.

5-HT receptor classification and nomenclature: towards a harmonization with the human genome.

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  • 1Novartis Pharma Ltd, Basel, Switzerland.


Molecular biology has dramatically advanced our knowledge and understanding of receptors for 5-hydroxytryptamine (5-HT). The existence of multiple 5-HT receptors defined using traditional pharmacological and biochemical approaches has now been amply confirmed, but gene products encoding putative "new" 5-HT receptors have also been discovered. In some cases, the absence of suitably selective agonists and antagonists has hampered determination of a physiological role for these gene products. This makes their classification as formally recognised receptors premature.

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