Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Med Genet. 1997 Jul;34(7):582-6.

Multiple lentigines syndrome (LEOPARD syndrome or progressive cardiomyopathic lentiginosis).

Author information

  • 1Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.

Abstract

The multiple lentigines syndrome is an autosomal dominant condition which has many similarities to Noonan syndrome, except in the most striking feature from which its name is derived. The less neutral but very apt mnemonic, LEOPARD syndrome, was first used by Gorlin et al to whom the major debt in the definition of this syndrome lies, that is, Lentigines, ECG abnormalities, Ocular hypertelorism/Obstructive cardiomyopathy, Pulmonary valve stenosis, Abnormalities of genitalia in males, Retardation of growth, and Deafness. Not previously included in the mnemonic is cardiomyopathy which is an important feature because it is associated with significant mortality.

PMID:
9222968
[PubMed - indexed for MEDLINE]
PMCID:
PMC1051000
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk