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1: Arthritis Rheum. 1977 Nov-Dec;20(8):1546-9.Links

Allopurinol hepatotoxicity. Case report and literature review.

Chawla SK, Patel HD, Parrino GR, Soterakis J, Lopresti PA, D'Angelo WA.

Significant hepatotoxicity due to allopurinol seems to be rare. Only 6 such cases have been recorded in the literature. The clinical and histopathologic findings of allopurinol-induced liver injury are variable in the previously reported cases. Described herein is another patient with allopurinol hepatotoxicity. Of interest is the similar histopathology between the present case and the two previously reported cases of allopurinol-induced granulomatous hepatitis; thus this is the third such recorded case. Allopurinol should be suspected when liver abnormalities occur following use of this drug.

PMID: 921828 [PubMed - indexed for MEDLINE]

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  • Allopurinol (Aloprim® , Zyloprim® )

    Allopurinol is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by re...

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