Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1997 Jul 11;277(5323):242-5.

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

Author information

  • 1Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.

Abstract

Platelet-derived growth factor (PDGF)-B-deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary microaneurysms that ruptured at late gestation. Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells. Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts.

PMID:
9211853
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk