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J Endocrinol Invest. 1997 Apr;20(4):211-4.

Recurrent thromboembolism as a hallmark of Cushing's syndrome.

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  • 1Divisione di Medicina Interna, Ospedale Civile di Giaveno, Torino, Italy.


The present report describes a 54-year-old woman with a history of recurrent thromboembolic events. The clinical and physical examination led to suspect Cushing's syndrome. Screening tests (urinary free cortisol excretion and 1 mg dexamethasone) were inconclusive, but a detailed endocrine work up confirmed the presence of ACTH-dependent hypercortisolism. The patient was cured by the removal of a ACTH-secreting microadenoma by transsphenoidal route. The present case provides a clinical demonstration of a previous experimental evidence that a hypercoagulable state is present in Cushing's syndrome.

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