Abstract
Low serum concentrations of HDL-cholesterol are well established markers for a high risk to develop coronary artery disease. The absence of coronary artery disease symptoms from some individuals with familial HDL deficiency demonstrates the presence of heterogeneity in this relation and points to an important role of etiologic and modifying factors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cholesterol, HDL / blood
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Coronary Disease / blood
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Coronary Disease / epidemiology
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Coronary Disease / genetics*
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Disease Models, Animal
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Genetic Diseases, Inborn / enzymology
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Genetic Diseases, Inborn / genetics
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Genetic Linkage
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Humans
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Lecithin Cholesterol Acyltransferase Deficiency / genetics
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Lipoproteins, HDL / biosynthesis
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Lipoproteins, HDL / deficiency*
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Lipoproteins, HDL / genetics*
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Phosphatidylcholine-Sterol O-Acyltransferase / genetics
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Risk Factors
Substances
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Cholesterol, HDL
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Lipoproteins, HDL
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Phosphatidylcholine-Sterol O-Acyltransferase