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Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42.

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.

Author information

  • 1Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr. Here we report the molecular cloning of a new member of the mammalian MAP kinase kinase group (MKK7) that functions as an activator of JNK. In vitro protein kinase assays demonstrate that MKK7 phosphorylates and activates JNK, but not the p38 or extracellular signal-regulated kinase groups of MAP kinase. Expression of MKK7 in cultured cells causes activation of the JNK signal transduction pathway. MKK7 is therefore established to be a novel component of the JNK signal transduction pathway.

PMID:
9207092
[PubMed - indexed for MEDLINE]
PMCID:
PMC23822
Free PMC Article
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