Genomics. 1997 Jun 15;42(3):479-82.

Reln(rl-Alb2), an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping.

Royaux I, Bernier B, Montgomery JC, Flaherty L, Goffinet AM.

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Department of Physiology, FUNDP Medical School, Namur, Belgium.

Abstract

The reeler Albany2 mutation (Reln(rl-Alb2) in the mouse is an allele of reeler isolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations of reelin mRNA, in which an 85-nt exon was absent. At the genomic level, the mutation was shown to be due to an intracisternal A-particle insertion leading to exon skipping. This appears to be the first observation of retrotransposon insertion during chlorambucil mutagenesis.

PMID:: 9205121; [PubMed - indexed for MEDLINE]

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Reln(rl-Alb2), an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping.

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