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    Genomics. 1997 Jun 15;42(3):479-82.

    Reln(rl-Alb2), an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping.

    Royaux I, Bernier B, Montgomery JC, Flaherty L, Goffinet AM.

    Department of Physiology, FUNDP Medical School, Namur, Belgium.

    The reeler Albany2 mutation (Reln(rl-Alb2) in the mouse is an allele of reeler isolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations of reelin mRNA, in which an 85-nt exon was absent. At the genomic level, the mutation was shown to be due to an intracisternal A-particle insertion leading to exon skipping. This appears to be the first observation of retrotransposon insertion during chlorambucil mutagenesis.

    PMID: 9205121 [PubMed - indexed for MEDLINE]

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    • Chlorambucil (Leukeran®)

      Your doctor has ordered the drug chlorambucil to help treat your illness. The drug can be taken by mouth in tablet form.

    • Source: AHFS Consumer Medication Information

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