Arch Dermatol. 1997 Jun;133(6):767-71.

Endogenous retroviral sequences in the pathogenesis of systemic autoimmune disease.

Walchner M, Leib-Mösch C, Messer G, Germaier H, Plewig G, Kind P.

Source

Department of Dermatology, Ludwig-Maximilians-Universität, München, Germany.

Abstract

OBJECTIVES:

To update information on endogenous retroviral sequences and discuss their role in systemic autoimmune disease.

DATA SOURCES:

Articles retrieved after MEDLINE search and personal communications and cooperation with the Institute of Virology.

DATA SYNTHESIS:

There are 2 modes of pathogenetic mechanisms through which endogenous retroviral sequences could cause systemic autoimmune disease: expression of endogenous retroviral gene products sharing antigenic determinants with cellular proteins; and activation or destruction of cellular genes as a consequence of insertional mutagenesis. Both mechanisms have been demonstrated in vitro and in vivo in animal models.

CONCLUSION:

Investigations on endogenous retroviral sequences in humans may offer new insights into the pathogenesis of autoimmune disease.

PMID:: 9197833; [PubMed - indexed for MEDLINE]

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