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Surg Clin North Am. 1997 Jun;77(3):509-28.

General principles of wound healing.

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  • 1Department of Surgery, Sinai Hospital of Baltimore, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.


Wound healing is a complex process involving different biologic and immunologic systems. Despite improvements in diagnostics and therapy, wound failures remain a clinical problem. The approach to a nonhealed wound is an interdisciplinary challenge that should not be underestimated. Better understanding of the complex wound-healing cascade helps our approach to wound healing and its possible failure. Manipulations of the involved immunologic features offer future therapeutic strategies.

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