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    Biochim Biophys Acta. 1997 May 27;1356(3):249-52.

    Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA.

    Penhoat A, Naville D, Jaillard C, Durand P, Bégeot M.

    INSERM-INRA U 418, Hôpital Debrousse, Lyon, France. pdurand@univ-lyon1.fr

    We present 2.59 kb of the 3'-non-coding region of the ACTH receptor cDNA that contains seven potential polyadenylation signals. Among these signals, five are functional as detected by 3'-RACE and are consistent with the transcripts of 1.8, 3.4 and 4 kb visualized on Northern blots. We propose that the most likely molecular mechanism for the multiple ACTH-R mRNA transcripts is the alternative use of polyadenylation signals.

    PMID: 9194567 [PubMed - indexed for MEDLINE]

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