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Nature. 1997 Jun 19;387(6635):773-6.

Double identity for proteins of the Bcl-2 family.

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  • 1Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA.


Bcl-2 is an oncogenic protein that acts by inhibiting programmed cell death. The mechanisms used by this and related anti-apoptotic proteins to protect cells from cytotoxic stimuli are now emerging, with the discovery that Bcl-2 can function both as an ion channel and as an adaptor or docking protein.

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