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Neuroradiology. 1997 May;39(5):381-5.

MRI of the brain and craniocervical junction in Morquio's disease.

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  • 1Department of Radiology, Hope Hospital, Salford, Manchester, UK.


We reviewed MRI of the brain and cervical spine in 11 patients with Morquio's disease. No abnormality was seen in the brain. The odontoid peg was abnormal in all patients, with varying degrees of cord compression due to an anterior soft tissue mass and indentation by the posterior arch of the atlas. The degree of cord compression was more marked than suggested by the symptoms and signs. We recommend MRI of the cervical spine in children with Morquio's disease before the development of neurological symptoms, to optimise the timing and type of surgical intervention.

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