J Virol. 1997 Jul;71(7):5703-5.

pIRS1 and pTRS1 are present in human cytomegalovirus virions.

Romanowski MJ, Garrido-Guerrero E, Shenk T.

Source

Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.

Abstract

The virus-coded proteins pIRS1 and pTRS1 were found associated with purified human cytomegalovirus virions. The proteins were not degraded when intact virions were treated with trypsin, which suggests that they are localized inside the viral particle. In transfection experiments pIRS1 and pTRS1 modestly activated expression from a reporter plasmid containing the viral major immediate-early promoter but did not influence the activity of a reporter carrying the irs1/trs1 immediate-early promoter. Both reporters were activated by the combination of pIRS1 or pTRS1 and pUL69, which is also present in virions.

PMID:: 9188653; [PubMed - indexed for MEDLINE]
PMCID:: PMC191821

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation. [J Virol. 1997]
Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation.
Romanowski MJ, Shenk T. J Virol. 1997 Feb; 71(2):1485-96.
Essential role for either TRS1 or IRS1 in human cytomegalovirus replication. [J Virol. 2009]
Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.
Marshall EE, Bierle CJ, Brune W, Geballe AP. J Virol. 2009 May; 83(9):4112-20. Epub 2009 Feb 11.
A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles. [J Virol. 1996]
A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles.
Winkler M, Stamminger T. J Virol. 1996 Dec; 70(12):8984-7.
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1. [J Virol. 2006]
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.
Hakki M, Marshall EE, De Niro KL, Geballe AP. J Virol. 2006 Dec; 80(23):11817-26. Epub 2006 Sep 20.
Mutant human cytomegalovirus lacking the immediate-early TRS1 coding region exhibits a late defect. [J Virol. 2002]
Mutant human cytomegalovirus lacking the immediate-early TRS1 coding region exhibits a late defect.
Blankenship CA, Shenk T. J Virol. 2002 Dec; 76(23):12290-9.

See reviews... See all...

Cited by 25 PubMed Central articles

The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. [J Virol. 2012]
The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1.
Chaumorcel M, Lussignol M, Mouna L, Cavignac Y, Fahie K, Cotte-Laffitte J, Geballe A, Brune W, Beau I, Codogno P, et al. J Virol. 2012 Mar; 86(5):2571-84. Epub 2011 Dec 28.
Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. [J Virol. 2010]
Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein.
Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. J Virol. 2010 Aug; 84(15):7803-14. Epub 2010 May 26.
The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. [J Virol. 2009]
The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment.
Buchkovich NJ, Maguire TG, Paton AW, Paton JC, Alwine JC. J Virol. 2009 Nov; 83(22):11421-8. Epub 2009 Sep 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

pIRS1 and pTRS1 are present in human cytomegalovirus virions.
pIRS1 and pTRS1 are present in human cytomegalovirus virions.
J Virol. 1997 Jul ;71(7):5703-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

pIRS1 and pTRS1 are present in human cytomegalovirus virions.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 25 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information