Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Virol. 1997 Jul;71(7):5620-3.

Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

Author information

  • 1Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.

Abstract

A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53-mediated transcription.

PMID:
9188637
[PubMed - indexed for MEDLINE]
PMCID:
PMC191805
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk