Chest. 1997 Jun;111(6):1766-7.

A paradoxical effect of bronchodilators.

Maury E, Ioos V, Lepecq B, Guidet B, Offenstadt G.

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Intensive Care Unit, Hôpital Saint Antoine, Paris, France.

Abstract

Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.

PMID:: 9187208; [PubMed - indexed for MEDLINE]

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