Send to

Choose Destination
See comment in PubMed Commons below
Acta Anaesthesiol Scand. 1997 May;41(5):647-50.

Reversal of multiorgan system dysfunction in sickle cell disease with plasma exchange.

Author information

  • 1Department of Medicine, University of Rochester School of Medicine & Dentistry, New York, USA.


A 23-year-old man with sickle cell anemia and multiorgan system dysfunction was treated with plasma exchange during a sickle cell crisis. The patient failed to respond to conventional treatment including hydration, blood transfusions, broad spectrum antibiotics, supplemental oxygen, and analgesics. The clinical picture resembled thrombotic thrombocytopenic purpura (TTP), and the patient responded dramatically to plasma exchange with reversal of a rapidly deteriorating clinical state. This case illustrates possible similarities in the pathophysiology of TTP and sickle cell crisis, and the value of plasma exchange in related critical disease states.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk