FEBS Lett. 1997 May 12;408(1):39-42.

Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.

Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP.

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Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland. Olivier.Boss@medecine.unige.ch

Abstract

Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering thermogenesis. The uncoupling protein-1 (UCP1) is the main effector of nonshivering thermogenesis in BAT and the recently described ubiquitous UCP2 [1] has been implicated in energy balance. In an attempt to better understand the biochemical events underlying nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library and isolated three clones: UCP2, UCP3L and UCP3S. The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle-specific and its expression was unaffected by cold acclimation. This new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle.

PMID:: 9180264; [PubMed - indexed for MEDLINE]

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UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. [Biochem Biophys Res Commun. 1997]
UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. Biochem Biophys Res Commun. 1997 Jun 9; 235(1):79-82.
Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis. [Physiol Biochem Zool. 2004]
Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis.
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Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes. [Diabetes. 1998]
Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.
Matsuda J, Hosoda K, Itoh H, Son C, Doi K, Hanaoka I, Inoue G, Nishimura H, Yoshimasa Y, Yamori Y, et al. Diabetes. 1998 Nov; 47(11):1809-14.
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Review Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4.
Bouillaud F, Couplan E, Pecqueur C, Ricquier D. Biochim Biophys Acta. 2001 Mar 1; 1504(1):107-19.
Review UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. [Biochim Biophys Acta. 2001]
Review UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.
Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B. Biochim Biophys Acta. 2001 Mar 1; 1504(1):82-106.

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Cited by 72 PubMed Central articles

Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease. [Transl Neurodegener. 2012]
Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease.
Ho PW, Ho JW, Liu HF, So DH, Tse ZH, Chan KH, Ramsden DB, Ho SL. Transl Neurodegener. 2012 Jan 13; 1(1):3. Epub 2012 Jan 13.
Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion. [PLoS One. 2012]
Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion.
Alves-Guerra MC, Aheng C, Pecqueur C, Masscheleyn S, Tharaux PL, Druilhe A, Ricquier D, Challet E, Miroux B. PLoS One. 2012; 7(8):e41846. Epub 2012 Aug 10.
Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. [Front Endocrinol (Lausanne). 2...]
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Boss O, Farmer SR. Front Endocrinol (Lausanne). 2012; 3:14. Epub 2012 Feb 6.

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tiss...
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FEBS Lett. 1997 May 12 ;408(1):39-42.

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