Pharmacol Ther. 1997;73(3):265-80.

S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.

Mato JM, Alvarez L, Ortiz P, Pajares MA.

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Instituto de Investigaciones Biomédicas, CSIC, Madrid, Spain.

Abstract

Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes coding for MAT, one expressed exclusively in the liver and a second enzyme present in all tissues. Molecular studies indicate that liver MAT exists in two forms: as a homodimer and as a homotetramer of the same oligomeric subunit. The liver-specific isoenzymes are inhibited in human liver cirrhosis, and this is the cause of the abnormal metabolism of methionine in these subjects.

PMID:: 9175157; [PubMed - indexed for MEDLINE]

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