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Neuroreport. 1997 Mar 24;8(5):1301-4.

The serotonin transporter gene and peer-rated neuroticism.

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  • 1Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK.

Abstract

Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires. We attempted to extend these findings using a selected extremes design and peer ratings. From a sample of 2085 individuals, each assessed on neuroticism by two independent peers, we selected 52 individuals from the top 5% and 54 individuals from the bottom 5%. No association was found for either a functional 44 bp insertion/deletion polymorphism in 5HTT regulatory sequence (5HTTLPR) or for a non-functional variable number tandem repeat 5HTT polymorphism.

PMID:
9175133
[PubMed - indexed for MEDLINE]
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