Abstract
Loss of sweating is a characteristic feature of multiple system atrophy (MSA) with autonomic failure, and widespread anhidrosis may lead to hyperthermia and collapse in a hot environment. Calcitonin gene-related peptide (CGRP) is present in the periglandular nerves around sweat glands and is a strong stimulant of methacholine (MCH)-mediated cholinergic sweating. The present study evaluated CGRP-related regulation of cholinergic sweating in patients with MSA. CGRP-induced potentiation of MCH-mediated cholinergic sweating was significantly reduced in MSA patients as compared with normal age-matched controls. These results suggest that regulation of sweating is extensively affected in MSA as a consequence of peptidergic dysfunction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Autonomic Nervous System Diseases / metabolism*
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Autonomic Nervous System Diseases / physiopathology
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Calcitonin Gene-Related Peptide / pharmacology*
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Cerebellar Diseases / metabolism*
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Cerebellar Diseases / physiopathology
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Drug Combinations
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Female
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Humans
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Hypotension, Orthostatic / physiopathology
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Male
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Methacholine Chloride / pharmacology
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Middle Aged
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Parasympathetic Nervous System / drug effects*
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Parasympathetic Nervous System / physiopathology*
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Parasympathomimetics / pharmacology
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Parkinson Disease / metabolism*
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Parkinson Disease / physiopathology
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Sweat / drug effects*
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Sweat / metabolism*
Substances
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Drug Combinations
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Parasympathomimetics
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Methacholine Chloride
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Calcitonin Gene-Related Peptide