Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Perspect Dev Neurobiol. 1996;4(1):3-18.

Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines.

Author information

  • 1Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Neuropoietic cytokines such as ciliary neurotrophic factor, leukemia inhibitory factor, and interleukin-6 are known to be responsible for a wide variety of effects on cells of the immune and nervous systems. The mechanisms by which such diverse effects are regulated and coordinated within cells is of central importance to the understanding of how these molecules function during development. This review discusses the receptor complexes through which neuropoietic cytokines signal and the mechanisms by which activation of specific enzymes such as the Jak family of kinases are transduced into changes of gene expression through molecules such as the Stat proteins. This review also discusses how this JAK-Stat signaling pathway is thought to interact with other known cascades, such as the mitogen-activated protein kinase pathway.

PMID:
9169915
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk