Age-related skin changes place older adults at risk for a variety of dermatologic problems, ranging from xerosis, or dry skin, to malignant melanoma, a life-threatening condition. Primary care providers must differentiate rashes caused by fungal infections, eczematous conditions, viral infections, drug reactions, and other common causes in this age group. Providers should be familiar with dermatologic therapy that may involve topical preparations, oral medications, and surgical methods. In addition, patient education about symptom treatments, skin hygiene, and preventive measures can greatly improve the clinical condition and quality of life of older adults.