Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 1997 May 30;272(22):14087-92.

Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity.

Author information

  • 1Division of Nephrology, Department of Medicine, San Francisco General Hospital, and Biomedical Sciences Program, University of California, San Francisco, California 94143, USA.

Abstract

The androgen and glucocorticoid hormones elicit divergent and often opposing effects in cells, tissues, and animals. A wide range of physiological and molecular biological evidence suggests that the receptors that mediate these effects, the androgen and glucocorticoid receptors (AR and GR, respectively), influence each other's transcriptional activity. We now show that coexpressed AR and GR indeed do interact at the transcriptional level and that this interaction is correlated with their ability to form heterodimers at a common DNA site, in vitro and in vivo. Furthermore, mutants that cannot heterodimerize do not inhibit each other's activity. These observations provide the first evidence that the opposing physiological effects of the androgen and glucocorticoid hormones are due to the direct physical interaction between their receptors at the transcriptional level.

PMID:
9162033
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk