Gene. 1997 Apr 11;189(1):89-94.

Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.

Source

Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. lhsu@smtplink.coh.org

Abstract

The structure of two human aldehyde dehydrogenase genes, ALDH7 and ALDH8, have been determined. The ALDH7 gene spans about 20 kb of the human genomic DNA and is composed of 9 coding exons. The ALDH8 gene is over 10 kb in length and consists of at least 10 exons. The ALDH8 gene contains an in-frame stop codon at the 17th codon position from the first initiator Met. The coding region of the ALDH7 gene shows about 86% nucleotide identity with the corresponding region of the ALDH8 gene. The numbers and positions of the introns of the two genes are conserved, suggesting that gene duplication is involved in the expansion of the ALDH gene family. The human ALDH7 and -8 genes have a closer evolutionary relationship with the human ALDH3.

PMID:: 9161417; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

AA05763/AA/NIAAA NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Genes and Gene Therapy - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. [Gene. 1996]
Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family.
Hsu LC, Chang WC. Gene. 1996 Oct 3; 174(2):319-22.
Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid. [Biochem J. 1999]
Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid.
Hsu LC, Chang WC, Hoffmann I, Duester G. Biochem J. 1999 Apr 15; 339 ( Pt 2):387-95.
Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. [Gene. 1994]
Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family.
Hsu LC, Chang WC, Yoshida A. Gene. 1994 Dec 30; 151(1-2):285-9.
Review Human aldehyde dehydrogenase gene family. [Eur J Biochem. 1998]
Review Human aldehyde dehydrogenase gene family.
Yoshida A, Rzhetsky A, Hsu LC, Chang C. Eur J Biochem. 1998 Feb 1; 251(3):549-57.
Review Molecular genetics of human aldehyde dehydrogenase. [Pharmacogenetics. 1992]
Review Molecular genetics of human aldehyde dehydrogenase.
Yoshida A. Pharmacogenetics. 1992 Aug; 2(4):139-47.

See reviews... See all...

Cited by 6 PubMed Central articles

Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. [Free Radic Biol Med. 2010]
Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.
Marchitti SA, Brocker C, Orlicky DJ, Vasiliou V. Free Radic Biol Med. 2010 Nov 15; 49(9):1432-43. Epub 2010 Aug 10.
Review Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. [Expert Opin Drug Metab Toxicol...]
Review Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.
Marchitti SA, Brocker C, Stagos D, Vasiliou V. Expert Opin Drug Metab Toxicol. 2008 Jun; 4(6):697-720.
Expression and initial characterization of human ALDH3B1. [Biochem Biophys Res Commun. 2007]
Expression and initial characterization of human ALDH3B1.
Marchitti SA, Orlicky DJ, Vasiliou V. Biochem Biophys Res Commun. 2007 May 11; 356(3):792-8. Epub 2007 Mar 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and ge...
Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.
Gene. 1997 Apr 11 ;189(1):89-94.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: