Display Settings:

Format

Send to:

Choose Destination
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5691-6.

Developmental parameters of cell death in the wing disc of Drosophila.

Author information

  • 1Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain.

Abstract

Apoptotic cell death in wing imaginal discs takes place in single cells or small clusters of neighboring cells. These cells are distributed throughout the anlage at early stages and in recognizable territories at late larval and pupal stages. Apoptotic cells remain in the epithelium 2-4 h, prior to being engulfed in place by hemolymph cells. Experimentally induced apoptosis in single cells or territories is accompanied by nonautonomous death of adjacent cells and of cells further away in adjacent territories. These effects are followed by changes in cell proliferation in both territories. Apogenetic mosaics in mutant discs show cell death throughout the anlage. Apoptosis provides a mechanism, in addition to cell proliferation control, for matching territories with different positional values or different genetic specifications.

PMID:
9159134
[PubMed - indexed for MEDLINE]
PMCID:
PMC20840
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk