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Mol Cell Biol. 1997 Jun;17(6):3125-36.

Cryptic signals and the fidelity of V(D)J joining.

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  • 1Division of Biology, California Institute of Technology, Pasadena 91125, USA. Lewis@immune.med.utoronto.ca


V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-cell precursors. To the extent that lymphopoiesis takes place throughout an animal's lifetime, recombination errors present an ongoing problem. One type of aberrant rearrangement ensues when DNA sequences resembling a V(D)J joining signal are targeted by mistake. This study investigates the type of sequence likely to be subject to mistargeting, the level of joining-signal function associated with these sequences, and the number of such cryptic joining signals in the genome.

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