Cytogenet Cell Genet. 1997;76(1-2):49-52.

FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.

Schiebel K, Mertz A, Winkelmann M, Gläser B, Schempp W, Rappold G.

Source

Institute of Human Genetics, University of Heidelberg, Germany.

Abstract

Recently, we reported the isolation of a new subfamily of serine-threonine protein kinases. This subfamily was shown to consist of at least four members. Sequencing and FISH mapping of all 4 members now reveals that the Y-homolog (PRKY) of the previously mapped PRKX gene (Xp22.3) is located in Yp11.2, in close vicinity to AMELY. The other two copies reside on Xq12-->q13 (PRKXP2) and 15q26 (PRKXP1, containing CA repeat STS D15S87) and represent pseudogenes.

PMID:: 9154127; [PubMed - indexed for MEDLINE]

Supplemental Content

Save items

Related citations in PubMed

Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. [Hum Mol Genet. 1997]
Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.
Schiebel K, Winkelmann M, Mertz A, Xu X, Page DC, Weil D, Petit C, Rappold GA. Hum Mol Genet. 1997 Oct; 6(11):1985-9.
Genes located in and near the human pseudoautosomal region are located in the X-Y pairing region in dog and sheep. [Chromosome Res. 1997]
Genes located in and near the human pseudoautosomal region are located in the X-Y pairing region in dog and sheep.
Toder R, Gläser B, Schiebel K, Wilcox SA, Rappold G, Graves JA, Schempp W. Chromosome Res. 1997 Aug; 5(5):301-6.
Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26. [Genome Res. 2001]
Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26.
Pujana MA, Nadal M, Gratacòs M, Peral B, Csiszar K, González-Sarmiento R, Sumoy L, Estivill X. Genome Res. 2001 Jan; 11(1):98-111.
Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. [Hum Genet. 1998]
Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.
Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L. Hum Genet. 1998 Oct; 103(4):523-4.
Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1. [Genomics. 1997]
Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.
Harun RB, Smith KK, Leek JP, Markham AF, Norris A, Morrison JF. Genomics. 1997 Jun 1; 42(2):349-52.

See reviews... See all...

Cited by 3 PubMed Central articles

Constitutional duplication of a region of chromosome Yp encoding AMELY, PRKY, and TBL1Y: implications for sex chromosome analysis and bone marrow engraftment analysis. [J Mol Diagn. 2007]
Constitutional duplication of a region of chromosome Yp encoding AMELY, PRKY, and TBL1Y: implications for sex chromosome analysis and bone marrow engraftment analysis.
Murphy KM, Cohen JS, Goodrich A, Long PP, Griffin CA. J Mol Diagn. 2007 Jul; 9(3):408-13.
The PKA-CREB system encoded by the honeybee genome. [Insect Mol Biol. 2006]
The PKA-CREB system encoded by the honeybee genome.
Eisenhardt D, Kühn C, Leboulle G. Insect Mol Biol. 2006 Oct; 15(5):551-61.
Review Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. [Am J Hum Genet. 1999]
Review Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.
Lau YF. Am J Hum Genet. 1999 Apr; 64(4):921-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
UniSTS
Genetic, physical, and sequence mapping reagents in the UniSTS database associated with the current articles through references on sequence tagged site (STS) submissions as well as automated searching of PubMed abstracts and full-text PubMed Central articles for marker names.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2...
FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.
Cytogenet Cell Genet. 1997 ;76(1-2):49-52.

PubMed
NMR relaxation data of water proton in normal tissues.
NMR relaxation data of water proton in normal tissues.
Physiol Chem Phys Med NMR. 1996 ;28(4):205-38.

PubMed
Repair of large experimental perforations of the tympanic membrane.
Repair of large experimental perforations of the tympanic membrane.
J Laryngol Otol. 1977 Sep ;91(9):767-78.

PubMed
Sexually transmitted diseases in men who have sex with men. Acquisition of gonor...
Sexually transmitted diseases in men who have sex with men. Acquisition of gonorrhea and nongonococcal urethritis by fellatio and implications for STD/HIV prevention.
Sex Transm Dis. 1997 May ;24(5):272-8.

PubMed
MR imaging of the infrapatellar fat pad of Hoffa.
MR imaging of the infrapatellar fat pad of Hoffa.
Radiographics. 1997 May-Jun ;17(3):675-91.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information