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Trends Biochem Sci. 1997 Apr;22(4):128-32.

Histone acetylation: chromatin in action.

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  • 1Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov

Abstract

Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.

PMID:
9149532
[PubMed - indexed for MEDLINE]
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