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Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human.
Centre d'Immunologie, INSERM-CNRS de Marseille Luminy, France.
We report here on the identification and genomic mapping of a novel member of the family of the ATP-binding cassette (ABC) transporters, ABC7, conserved in mouse and in humans. The ABC7 gene encodes a protein with the typical features of half-transporters, such as those involved in translocation of antigenic peptides or in peroxisomal disorders. ABC7 shows a ubiquitous expression pattern and maps to the X chromosome both in mouse and in humans. The high sequence similarity to those of two yeast half-transporters supports once again the extreme evolutionary conservation of this family of proteins.
PMID: 9143506 [PubMed - indexed for MEDLINE]
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Cited by 1 PubMed Central article
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Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease.
Lewis RA, Shroyer NF, Singh N, Allikmets R, Hutchinson A, Li Y, Lupski JR, Leppert M, Dean M.
Am J Hum Genet. 1999 Feb; 64(2):422-34.
[Am J Hum Genet. 1999]