[Biologic availability and "1st pass" effect of dr...[Fortschr Med. 1977]

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1: Fortschr Med. 1977 Jul 28;95(28):1765-6, 1774-80.Links

[Biologic availability and "1st pass" effect of drugs]

[Article in German]

Rietbrock N, Keller F.

Bioavailability and "first pass"-effect are of increasing importance in Clinical Pharmacology. Bioavailability is the rate and above all the extent to which a drug reaches the systemic circulation. Reduced bioavailability may result from the physico-chemical properties of the drug, its solubility in the intestinal tract and its ability to permeate the gut wall. Reduced bioavailability may also result from a "first pass"-effect if the drug is metabolized during absorption by the enteral mucosa or during its first liver passage. Some conclusions may be drawn which are of importance for the clinic and pharmacy from the presented empirical and theoretical examples.

PMID: 914146 [PubMed - indexed for MEDLINE]

[The bioavailability of orally administered drugs with special regard to the liver as a filter for foreign matter] [Schweiz Med Wochenschr. 1980]
An overview of the analysis and interpretation of bioavailability studies in man. [Arzneimittelforschung. 1976]
Review[Bioavailability and its significance in pharmacotherapy] [Pol Merkur Lekarski. 2003]
The rate and extent of oral bioavailability versus the rate and extent of oral absorption: clarification and recommendation of terminology. [J Pharmacokinet Pharmacodyn. 2001]
ReviewFirst-pass elimination. Basic concepts and clinical consequences. [Clin Pharmacokinet. 1984]

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[Biologic availability and "1st pass" effect of drugs]

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