Virus Res. 1997 Apr;48(1):11-8.

A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.

Source

Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.

Abstract

We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain motifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia virus p37, encoded by the F13L gene, which is required for envelopment and spread of the virus. The similarity to phospholipase D provides insight into the mechanisms and evolution of these processes.

PMID:: 9140189; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Sequence and analysis of a swinepox virus homologue of the vaccinia virus major envelope protein P37 (F13L). [J Gen Virol. 2000]
Sequence and analysis of a swinepox virus homologue of the vaccinia virus major envelope protein P37 (F13L).
Bárcena J, Lorenzo MM, Sánchez-Puig JM, Blasco R. J Gen Virol. 2000 Apr; 81(Pt 4):1073-85.
Similarities in the induction of post-Golgi vesicles by the vaccinia virus F13L protein and phospholipase D. [J Virol. 2002]
Similarities in the induction of post-Golgi vesicles by the vaccinia virus F13L protein and phospholipase D.
Husain M, Moss B. J Virol. 2002 Aug; 76(15):7777-89.
Non-essential genes in the vaccinia virus HindIII K fragment: a gene related to serine protease inhibitors and a gene related to the 37K vaccinia virus major envelope antigen. [J Gen Virol. 1988]
Non-essential genes in the vaccinia virus HindIII K fragment: a gene related to serine protease inhibitors and a gene related to the 37K vaccinia virus major envelope antigen.
Boursnell ME, Foulds IJ, Campbell JI, Binns MM. J Gen Virol. 1988 Dec; 69 ( Pt 12):2995-3003.
Review Phospholipase D structure and regulation. [Chem Phys Lipids. 1999]
Review Phospholipase D structure and regulation.
Frohman MA, Morris AJ. Chem Phys Lipids. 1999 Apr; 98(1-2):127-40.
Review An update on the vaccinia virus genome. [Virology. 1993]
Review An update on the vaccinia virus genome.
Johnson GP, Goebel SJ, Paoletti E. Virology. 1993 Oct; 196(2):381-401.

See reviews... See all...

Cited by 2 PubMed Central articles

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. [PLoS One. 2010]
Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.
Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura-Takagi Y, Morita N, Sato Y, Saruta C, Nishibe H, Sadakata T, et al. PLoS One. 2010 Nov 11; 5(11):e13932. Epub 2010 Nov 11.
Envelope formation is blocked by mutation of a sequence related to the HKD phospholipid metabolism motif in the vaccinia virus F13L protein. [J Virol. 1999]
Envelope formation is blocked by mutation of a sequence related to the HKD phospholipid metabolism motif in the vaccinia virus F13L protein.
Roper RL, Moss B. J Virol. 1999 Feb; 73(2):1108-17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A human homolog of the vaccinia virus HindIII K4L gene is a member of the phosph...
A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.
Virus Res. 1997 Apr ;48(1):11-8.

PubMed
Overview: maintenance therapy in psychiatry: I. Schizophrenia.
Overview: maintenance therapy in psychiatry: I. Schizophrenia.
Am J Psychiatry. 1975 Dec ;132(12):1237-45.

PubMed
Memory and complex dynamics in cardiac Purkinje fibers.
Memory and complex dynamics in cardiac Purkinje fibers.
Am J Physiol. 1997 Apr ;272(4 Pt 2):H1826-32.

PubMed
A mycobacterial extracytoplasmic function sigma factor involved in survival foll...
A mycobacterial extracytoplasmic function sigma factor involved in survival following stress.
J Bacteriol. 1997 May ;179(9):2922-9.

PubMed
Connexin 26 mutations in hereditary non-syndromic sensorineural deafness.
Connexin 26 mutations in hereditary non-syndromic sensorineural deafness.
Nature. 1997 May 1 ;387(6628):80-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information