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Bioessays. 1997 Apr;19(4):307-15.

Cyclins, cyclin-dependent kinases and differentiation.

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  • 1Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA.


Cyclin-dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non-cycling, differentiated cells. This review surveys the available information about cyclins and cyclin-dependent kinases in differentiated cells and explores the possibility that these proteins may have important functions that are independent of cell cycle regulation.

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