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    Genome Res. 1995 Sep;5(2):185-94.

    Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation.

    Del Mastro RG, Wang L, Simmons AD, Gallardo TD, Clines GA, Ashley JA, Hilliard CJ, Wasmuth JJ, McPherson JD, Lovett M.

    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-8591, USA.

    To date, only a small percentage of human genes have been cloned and mapped. To facilitate more rapid gene mapping and disease gene isolation, chromosome 5-specific cDNA libraries have been constructed from five sources. DNA sequencing and regional mapping of 205 unique cDNAs indicates that 25 are from known chromosome 5 genes and 138 are from new chromosome 5 genes (a frequency of 79.5%). Sequence complexity estimates indicate that each library contains -20% of the approximately 5000 genes that are believed to reside on chromosome 5. This study more than doubles the number of genes mapped to chromosome 5 and describes an important new tool for disease gene isolation.

    PMID: 9132272 [PubMed - indexed for MEDLINE]

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